Review article sinapic acid and its derivatives as. Sinapic acid is an hydroxycinnamic acid derivative that occurs naturally in brassicaceae species. The literature reveals that sinapic acid is a bioactive phenolic acid and has the potential to attenuate various chemically. Sinapic acid regulates glucose homeostasis by modulating. The action of sinapic acid and its alkyl esters as potential antioxidants has been investigated. Pdf sinapic acid is a natural phenolic acid found in fruits, vegetables, and cereals, exerting numerous pharmacological effects. Sinapic acid can form dimers with itself and ferulic acid in cereal cell walls and therefore may have a sim. Antioxidant constituents of three selected red and green. It can be estimated that the free sa content in rsm may range from 0. Extreme high moderate low section 1 chemical product and company identification product name sinapic acid statement of hazardous nature considered a hazardous substance according to osha 29 cfr 1910. Pdf sinapic acid and its derivatives as medicine in oxidative. Sinapic acid is 1 of the 4 most common hydroxycinnamic acids.
Sinapic acid constitutes over 73% of the free phenolic acids while sinapine, the choline ester of sinapic acid, is the main phenolic ester in canola seeds about 80% of the total phenolics. Sinapic acid, a phenolic acid, has been reported to inhibit the dpph free radical 33. Sinapinic acid sinapic acid matrix 1 gram sinapinic. Sinapic acid c11h12o5, phenylpropanoid cinnamic acid deriv. A kinetic approach in the evaluation of radicalscavenging. It serves well as a matrix for maldi due to its ability to absorb laser radiation and to also donate protons to the analyte of interest. For thousands of years, the natural products have played an important role throughout the world in the treatment and prevention of human diseases. Sinapic acid is a phenylpropanoid compound that is abundant in cereals, nuts, oil seeds, and berries and has been reported to exhibit a wide range of pharmacological properties. It is a useful matrix for a wide variety of peptides and proteins. Refining removes most of the nontriacylglycerol components, including many sinapic acid derivatives typical for rapeseed. Sinapinic acid posssess potent antitumor activity, induces apoptosis of tumor cells1.
In this study, we investigated the antiinflammatory effect of sinapic acid in carbon tetrachloride ccl4induced acute hepatic injury in rats. Sinapic acid shows antioxidant, antimicrobial, antiin. Sinapic acid is one of the phenolic acids that widely distributed in edible plants such as cereals, nuts, oil seeds and berries. Uses, benefits, properties, and effects of sinapic acid. Sinapic acid 3, 5dimethoxy 4hydroxy cinnamic acid is one such phytochemical which lacks scientific validation for its folklore use. It is a commonly used matrix in maldi mass spectrometry. Effect of conventional and microwave toasting on sinapic acid. Sinapic acid shows antioxidant, antimicrobial, antiinflammatory, anticancer, and anxiolytic. Hydroxycinnamic acids belong to the class of phenolic acids with bioactive carboxylic acids. Effect of rosmarinic acid and sinapic acid on oxidative. Pdf the effects of sinapic acid on the development of. Sinapic acid reduces the uvainduced production of pge 2 and camp. Nutritional and physiological effects of dietary sinapic.
Sinapic acid is a phytochemical found in various edible plants such as spices, citrus and berry fruits, vegetables 1012, cereals, and oilseed crops, 14. In the present study, attempting to investigate the effect of sinapic acid on biochemical parameters related to glucose and lipid metabolism as well as oxidative stress in the blood serum in conditions of estrogen deficiency, the rats were administered two doses of sinapic acid. The objective of this work was to study the potential of near infrared reflectance spectroscopy nirs to analyze sae. Sinapic acid esters sae are important antinutritional compounds of the seed of rapeseed brassica napus l. Chemopreventive effect of sinapic acid on head and neck. Sinapic acid and its derivatives as medicine in oxidative stressinduced diseases and aging chunyechen key laboratory of biorheological science and technology, ministry of education, bioengineering college, chongqing university, chongqing, china correspondence should be addressed to chunye chen.
Sinapine was discovered by etienne ossian henry in 1825. Sigmaaldrich offers a number of sinapic acid products. Rhizome, acts as an inhibitor of hdac, with an ic50 of 2. The effect of these phenolic constituents on the oxidative stability of the oil was studied using rapeseed and turnip rapeseed oil samples resulting from different expelling conditions and refinement steps. Research article sinapic acid prevents hypertension and. It is a naturally occurring carboxylic acid belongs to phenylpropanoid family. The main phenolic compounds namely sinapine sp, sinapoyl glucose sg, sinapic acid sa and canolol were identified and quantified by hplcdad. A kinetic approach was used to determine the radical scavenging activities of sinapic acid and its derivatives. Sinapine typically occurs in the outer seed coat of oil crops and is plentiful in some types of press cake leftover after vegetable. Sinapic acid 3,5dimethoxy4hydroxycinnamic acid is an orally bioavailable phytochemical, extensively found in spices, citrus and berry fruits, vegetables, cereals, and oilseed crops and is known to exhibit antioxidant, antiinflammatory, anticancer, antimutagenic, antiglycemic, neuroprotective, and antibacterial activities. Determination of sinapic acid derivatives in canola. Predicted data is generated using the us environmental protection agencys episuite. Sinapic acid is a natural phenolic acid found in fruits, vegetables, and cereals, exerting numerous pharmacological effects. The most active antioxidative component of canola meal was identified as 1.
Sinapic acid and its derivatives as medicine in oxidative. Research article sinapic acid prevents hypertension and cardiovascular remodeling in pharmacological model of nitric oxide inhibited rats thangarasu silambarasan1, jeganathan manivannan1,2, mani krishna priya2, natarajan suganya2, suvro chatterjee2,3, boobalan raja1 1. Showing all foods in which the polyphenol sinapic acid is. The literature reveals that sinapic acid is a bioactive phenolic acid and has the. Amino acid nitrogen, soluble protein, acid instructions for use author. The aim of the study was to investigate the influence of sinapic acid on biochemical parameters related to glucose and lipid metabolism, as well as markers of antioxidant abilities and parameters of oxidative damage in the blood serum in estrogendeficient rats. Technical details about sinapic acid, learn more about the structure, uses, toxicity, action, side effects and more sinapic acid also known as.
The sham and ovx control rats received water with the same amount of tween 20, in the same volume of 2mlkg p. Sinapic acid and its derivatives wiley online library. Cardiovascular diseases are one of the most common complications of type 2 diabetes. The literature reveals that sinapic acid is a bioactive phenolic. Sinapic acid constitutes over 73% of the free phenolic acids while sinapine, the choline ester of sinapic acid, is the main phenolic ester in canola seeds about 80% of the total phenolics 4. By contrast, the peroxidase isoenzymes from stems of vigna angularis oxidized sinapic acid and sinapyl alcohol quite slowly but rapidly oxidized compounds with a 4hydroxyphenyl or a guaiacyl group. Sinapine is an alkaloidal amine found in some seeds, particularly oil seeds of plants in the family brassicaceae. Part or all of this entry has been imported from the 19 edition of websters dictionary, which is now free of and hence in the public domain. Pdf sinapic acid 3,5dimethoxy4hydroxycinnamic acid is an orally bioavailable phytochemical. Over 60% of currently used anticancer agents are derived in one way or another from natural sources. Rapeseed oil is usually expelled from the seed at high temperatures.
The most significant phenolic compounds in canola seed are sinapic acid derivatives fig. Explanation of the value, properties, uses, effects and benfits of sinapic acid. Instructions for use sinapinic acid revision c author. Extrasynthese, 30 years of expertise in phenylpropanoid cinnamic acid deriv. Derivatives of sinapic acid are characteristic compounds of the brassicaceae family. Sinapinic acid is an ideal choice for large peptides or proteins with molecular weights larger than 10 kda. Sinapic acid and its derivatives as medicine in oxidative stress. The objective of this work was to study the potential of near infrared reflectance spectroscopy nirs to analyze sae content intactseed samples of the genus brassica. Showing all foods in which the polyphenol sinapic acid is found food composition. It is widely distributed in the plant kingdom and is obtained from various sources such as mustard, rye, berries and vegetables 5. Solubility of protocatechuic acid, sinapic acid and. They are considered the leading cause of death among diabetics. The highest ferulic acid, sinapic acid, transcinnamic acid, and pcoumaric acid 1. One of the mechanisms underlying diabetic cardiovascular complications is oxidative stress.
The aim of the study was to investigate the effect of rosmarinic acid ra and sinapic acid sa on. Sinapic acid is widespread in the plant kingdom fruits, vegetables, cereal grains, oilseed crops, and some spices and medicinal plants and is common in human diet. Sinapinic acid is an ideal choice as a maldims matrix for large peptides or proteins with molecular weights larger than 10 kda. Apoplastic peroxidase isoenzymes from stems of nicotiana tabacum rapidly oxidized sinapic acid and sinapyl alcohol, in addition to 4coumaric acid, ferulic acid and coniferyl alcohol.
Sinapinic acid sinapic acid is a phenolic compound isolated from hydnophytum formicarum jack. Nondestructive assessment of sinapic acid esters in. Sinapic acid constitutes up to 15% of total phenolics in rapeseed meal rsm and up to 99% of phenolic acids released from esters and glucosides in rapeseed flours krygier et al. Derivatives of sinapic acid are characteristic compounds.
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